How Do Bacteriophages Kill Bacteria in Phage Therapy?
Bacteriophages that specifically kill bacteria might help solve the growing problem of bacterial infections. The increasing number of antibiotic-resistant bacterial strains is a serious problem in contemporary medicine. What is important is the fact that these bacteria do not implicate resistance to phage lysis mechanisms. Lytic bacteriophages are able to kill antibiotic-resistant bacteria at the end of the phage infection cycle. Most of them utilize two-component lysis systems to destroy a bacterial cell wall in order to release progeny virions. Thus, the development of phage therapy is a potential way to improve the treatment of bacterial infections.
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