Hexane is used to extract edible oils from seeds and vegetables, as a special purpose solvent and cleaning agent. Acute (short-term) inhalation of high concentrations of hexane in humans can cause mild central nervous system (CNS) effects including dizziness, lightheadedness, mild nausea, and headache. Chronic (long-term) exposure to airborne hexane has been associated with polyneuropathy in humans, manifested by numbness of extremities, muscle weakness, blurred vision, headaches, and fatigue. Neurotoxic effects were also shown in rats. There is currently no information on the carcinogenic effects of hexane in humans or animals. The EPA classifies hexane as a Category D, not classifiable for human carcinogenicity.

use
The main use of hexane sds is as a solvent for the extraction of edible oils from seed and vegetable crops (e.g. soybeans, peanuts, corn). (6)
Commercial grade hexane is used as a solvent for glues (rubber cement, adhesives), varnishes, and inks. (3,6)
Hexane is also used as a cleaning agent (degreaser) in the printing industry. (6) Hexane is used as a liquid for cryogenic thermometers. (2,6,8)

Sources and Potential Exposure
The most likely route of human exposure to hexane is inhalation. Individuals are most likely to be exposed to hexane in the workplace. Monitoring data show that hexane is a widespread air pollutant. (1,2)
Assess personal exposure
Laboratory tests can detect the breakdown products of hexane in urine.

Health Hazard Information
Acute effects:
Acute inhalation of high concentrations of hexane in humans has resulted in mild central nervous system depression. Central nervous system effects included dizziness, vertigo, mild nausea and headache in humans. (1-3)
Acute exposure to hexane vapor may cause dermatitis and eye and throat irritation in humans. (2) Acute animal tests in rats show that hexane has low acute toxicity due to inhalation and ingestion.

Chronic inhalation of hexane has been associated with sensorimotor polyneuropathy in humans, manifested by numbness in extremities, muscle weakness, blurred vision, headache, and fatigue. (1,2,5-7) Chronic inhalation exposure in rats exhibited neurotoxic effects.