Is IUI Process Painful? This is a common concern among individuals considering intrauterine insemination (IUI) as a fertility treatment. The good news is that IUI is generally a mild and well-tolerated procedure. During the process, a thin catheter is used to place washed sperm directly into the uterus, which helps bypass natural barriers and increases the chances of conception. Most people describe the sensation as mild discomfort rather than actual pain. Some may feel slight cramping or pressure similar to what occurs during a routine pelvic exam. These sensations typically subside quickly after the procedure. The level of discomfort experienced can vary from person to person. Factors such as individual pain tolerance, cervical sensitivity, and whether fertility medications are used can influence how one feels during IUI.