Polmacoxib Capsules 2mg uses

Polmacoxib Capsules 2mg uses

What Is Polmacoxib?

Polmacoxib is a selective COX‑2 inhibitor NSAID, also with mild carbonic anhydrase inhibition. Unlike non-selective NSAIDs, it's designed to reduce pain and inflammation while minimizing gastrointestinal side effects

✅ Approved Uses

A). Primary – Osteoarthritis of the hip and knee: relieves pain, stiffness, and improves joint function

B). Other potential indications – Rheumatoid arthritis, ankylosing spondylitis, postoperative acute pain (e.g. dental, surgical), and menstrual pain

⚙️ Mechanism of Action

a). COX‑2 suppression lowers pro‑inflammatory prostaglandins, reducing pain and swelling.

b). Carbonic anhydrase uptake via red blood cells enhances delivery to inflamed joints, maintaining low systemic exposure

💊 Dosage & Administration

a). Typical dose: 2mg orally once daily with meals; do not exceed 2mg/day

b). Pharmacokinetics: T_max ~5–6 hours, half‑life ~130 hours, primarily fecal excretion

🧪 Efficacy & Clinical Trials

a). Demonstrated efficacy comparable to celecoxib in reducing WOMAC pain scores in Phase III osteoarthritis trials.

b). Higher doses (e.g. 4–8mg) showed dose-dependent benefits; 2mg is preferred for safety and effectiveness .

⚠️ Side Effects & Warnings

a). Common: headache, nausea, dyspepsia, dizziness, abdominal discomfort, diarrhea, peripheral edema

b). Serious but rare: gastrointestinal bleeding/ulcers; cardiovascular risks (e.g. hypertension, edema); hepatotoxicity/renal issues .

c). Contraindications/caution in: heart/kidney/liver disease, uncontrolled hypertension, peptic ulcer, NSAID allergy, third-trimester pregnancy, breastfeeding .

d). Drug interactions: anticoagulants (e.g. warfarin), ACE inhibitors, diuretics, lithium, methotrexate, corticosteroids, SSRIs .

e). Advice: take with food, avoid alcohol, use caution if driving (due to dizziness) .

💰 Regulatory Approval

In India, DCGI approved 2mg polmacoxib (Acelex) on February 14, 2023 for idiopathic primary osteoarthritis of hip and knee.

🏭 Elkos Healthcare & Polmacoxib 2mg

Elkos Healthcare is a WHO‑GMP & ISO 9001 certified pharma company in Haryana, offering capsules — including polmacoxib 2mg — via PCD pharma franchise and third-party manufacturing. Their Fawn Incor/Coxpol‑2 capsules are indicated for:

a). Osteoarthritis

b). Rheumatoid arthritis

c). Postoperative pain relief

Contact Elkos Healthcare

contact number: +91-96930-22222
Website: www.elkosgroup.in
Email: elkos7777@gmail.com
Address:Plot NO.246 HSIIDC Industrial EstateAlipur, Barwala, Panchkula-134118 Haryana, India.

💡 Final Thoughts

Polmacoxib 2mg offers targeted pain relief with a more favorable GI profile compared to non-selective NSAIDs. However, like all NSAIDs, it carries cardiovascular and renal risks—so use only as prescribed. Elkos Healthcare supplies quality polmacoxib capsules via their manufacturing and franchise channels.