Sepsis Infections with SAA Marker
It has been proposed that some of the mediators released during the systemic inflammatory response to infection could serve as indicators of the severity of sepsis. SAA is a fast-responding acute phase marker. It is an apolipoprotein that attaches to high-density lipoproteins quickly after they are synthesized. This binding affects cholesterol metabolism during inflammatory situations, leading to phagocitic cell and lymphocyte adhesion and chemotaxis. About 24 hours after the inflammatory process begins, serum concentrations of SAA reach their maximum and then gradually decline. Responses to relatively insignificant inflammatory stimuli can trigger SAAs.
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