Introduction

Regorafenib is a targeted cancer therapy used primarily to treat certain types of advanced cancer, including:

Colorectal cancer: It is often prescribed for patients with metastatic colorectal cancer that has progressed after other treatments.

Gastrointestinal stromal tumors (GIST): It may be used in cases of GIST that are no longer responding to imatinib and sunitinib.

Hepatocellular carcinoma (HCC): Approved for patients with liver cancer who have been previously treated.

Mechanism of action
Regorafenib works by inhibiting several kinases involved in tumor growth and angiogenesis (the formation of new blood vessels that supply the tumor). This multi-targeted approach helps slow or stop the growth of cancer cells.

Administration
Form: It is taken orally in tablet form.

Dosage: Usually prescribed once daily, with specific guidelines regarding food intake.
Side Effects

Common side effects of Regorafenib?

Common side effects of regorafenib can include:

Fatigue: Many patients experience tiredness or weakness.
Diarrhea: Frequent loose stools are a common issue.
Hand-foot skin reaction: This includes redness, swelling, and pain on the palms of the hands and soles of the feet.
Nausea: Some individuals may feel nauseous or experience vomiting.
Loss of appetite: Decreased appetite can lead to weight loss.
Hypertension: Elevated blood pressure may occur.
Rash: Skin reactions, including rash or dry skin, can develop.
Mouth sores: Some patients may experience sores or ulcers in the mouth.
If you experience any side effects, especially severe or persistent ones, it's important to communicate with your healthcare provider for management strategies and Regorafenib Price in Philippines.

Serious side effects of regorafenib?

Serious side effects of regorafenib can include:

Liver Problems: Elevated liver enzymes can indicate liver damage or dysfunction, which may require monitoring and potentially stopping the medication.

Gastrointestinal Perforation: There is a risk of holes forming in the gastrointestinal tract, which is a medical emergency.

Severe Hypertension: Significant increases in blood pressure can occur, potentially requiring management.

Hemorrhage: There is a risk of severe bleeding in various parts of the body.

Hand-Foot Skin Reaction: While common, severe reactions can occur that may lead to significant discomfort and require dose adjustments.

Heart Issues: There may be a risk of heart-related problems, including heart attacks or arrhythmias.

Severe Allergic Reactions: Though rare, some patients may experience life-threatening allergic reactions.

If you experience any severe symptoms or changes in your health while taking regorafenib, it's crucial to seek medical attention promptly. Regular monitoring and communication with your healthcare provider can help manage these risks effectively.

Monitoring
Patients on regorafenib require regular monitoring for side effects, especially liver function and blood pressure.

If you have further questions or need specific details about regorafenib, feel free to ask!

What is the price of Regorafenib?

Stivarga (regorafenib) is a member of the multikinase inhibitor drug class and is commonly used for colorectal cancer, gastrointestinal stromal tumors, and hepatocellular carcinoma. The Price of Regorafenib 40 mg oral tablet can be around $24,151 for a supply of 84 tablets, depending on the pharmacy you visit. And you can buy it from a trusted pharmacy.